Uncovering New Mechanisms of LKB1-Mediated Tumor Suppression

May 14th - 17th, 2020



Chaired By

 Russell Jones, McGill University
 Reuben Shaw, The Salk Institute


Important Dates

 03/14/2020 - Travel Form )
 04/14/2020 - Abstracts )


Venue Information

Geneva National Resort
1221 Geneva National Avenue, South
Lake Geneva, WI 53147
262.245.7000

www.genevanationalresort.com


Travel Agent Information

 Meeting #: Refer to your packet.
 Hours: 8:00am – 8:00 pm EST M-F
 Domestic: 669-210-8002
 International : 623-516-6140


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Program Description

The tumor suppressor gene STK11, which encodes the serine/threonine kinase LKB1, is one of the most frequent hotspot mutations in human cancer. LKB1 plays multi- faceted roles in cancer, being implicated in both hamartomatous polyposis syndromes and malignant disease, including lung cancer (>30% of lung cancers display STK11 mutations). However, there has been limited progress in developing therapies to treat patients with LKB1- deficient tumors. Recent advances in understanding the tumor suppressor functions of LKB1, including regulation of inflammation, epigenetics, and anti-tumor immune responses, holds new promise for translating fundamental scientific discoveries to the clinic. Our Forbeck Meeting proposal on LKB1-mediated tumor suppression will bring together the top scientists and clinicians to discuss recent advances in LKB1 biology, led by two leaders in the field: Drs. Russell Jones (former Forbeck Scholar) and Reuben Shaw (former Forbeck Scholar mentor). The long- term vision of the meeting is to expand therapeutic options for patients with PJS or LKB1- deficient tumours by targeting novel aspects of LKB1-mediated tumor suppression.


Participant Information

Participant Institution

Airport Information

Milwaukee's General Mitchell International Airport (MKE) is the preferred airport as it is only 45 minutes from the meeting location.

  • Arrivals - Thursday at 1 PM, 3 PM and 6 PM
  • Departures - Sunday at 10 AM and 12 PM

Chicago's O'Hare Airport (ORD) is 1 1/2 hours from the meeting location without traffic. The Foundation can only accommodate 1 pick up per day at O'Hare. If you absolutely must fly into O'Hare (ie: International Flights) the Foundation will have the following pick up times at O'Hare:

  • Arrivals - Thursday at 3 PM
  • Departures - Sunday at 10 AM

Any other arrival times at Chicago's O'Hare airport must be arranged and paid for by the individual. You are welcome to arrive on Wednesday.


Abstracts

The abstracts should be only one or two paragraphs outlining the theme of your presentation and should reflect the objective and spirit of the meeting (see above). Abstracts will be circulated about one week before the meeting. The meeting organizer will start requesting them a month before the meeting.


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