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Uncovering New Mechanisms of LKB1-Mediated Tumor Suppression

October 14–17, 2021

Original Dates: May 14-17, 2020

Chaired By

 Russell Jones, PhD, Van Andel Institute
 Reuben Shaw, PhD, Salk Institute

Important Dates

 03/13/2021 -  Travel Form Due
 04/13/2021 -  Abstracts Due

Venue Information

Geneva National Resort
1221 Geneva National Avenue, South
Lake Geneva, WI 53147

Travel Agent Information

 Meeting #: Refer to your packet.
 Hours: 8:00am – 8:00 pm EST M-F
 Domestic: 669-210-8002
 International : 623-516-6140

About the Forbeck Foundation

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Program Description

The tumor suppressor gene STK11, which encodes the serine/threonine kinase LKB1, is one of the most frequent hotspot mutations in human cancer. LKB1 plays multi- faceted roles in cancer, being implicated in both hamartomatous polyposis syndromes and malignant disease, including lung cancer (>30% of lung cancers display STK11 mutations). However, there has been limited progress in developing therapies to treat patients with LKB1- deficient tumors. Recent advances in understanding the tumor suppressor functions of LKB1, including regulation of inflammation, epigenetics, and anti-tumor immune responses, holds new promise for translating fundamental scientific discoveries to the clinic. Our Forbeck Meeting proposal on LKB1-mediated tumor suppression will bring together the top scientists and clinicians to discuss recent advances in LKB1 biology, led by two leaders in the field: Drs. Russell Jones (former Forbeck Scholar) and Reuben Shaw (former Forbeck Scholar mentor). The long- term vision of the meeting is to expand therapeutic options for patients with PJS or LKB1- deficient tumours by targeting novel aspects of LKB1-mediated tumor suppression.

Forum Participants

Participant Institution
Lillian J. Eichner, PhD Salk Institute for Biological Studies
Jeffrey Engelman, MD, PhD Novartis Institutes for BioMedical Research, Inc.
John V. Heymach, MD, PhD MD Anderson Cancer Center
Russell Jones, PhD Van Andel Institute
Ji Yeon Kim, PhD University of Illinois at Chicago College of Medicine
Tomi P. Mäkelä, MD, PhD University of Helsinki
Heidi McBride, PhD McGill University
Lisa Osborne, PhD University of British Columbia
Thales Papagiannakopoulos, PhD NYU Langone
Franck Polleux, PhD Columbia University
Reuben Shaw, PhD Salk Institute
Monte Winslow, PhD Stanford University
Kwok-Kin Wong, MD, PhD NYU Langone

Forum Scholars

Scholar Institution
Vajira Weerasekara, PhD Massachusetts General Hospital Cancer Center; Harvard Medical School

Airport Information

Milwaukee's General Mitchell International Airport (MKE) is the preferred airport as it is only 45 minutes from the meeting location.

  • Arrivals - Thursday at 1 PM, 3 PM and 5 PM
  • Departures - Sunday at 10 AM and 12 PM

Chicago's O'Hare Airport (ORD) is 1 1/2 hours from the meeting location without traffic. The Foundation can only accommodate 1 pick up per day at O'Hare. If you absolutely must fly into O'Hare (ie: International Flights) the Foundation will have the following pick up times at O'Hare:

  • Arrivals - Thursday at 3 PM
  • Departures - Sunday at 10 AM

Any other arrival times at Chicago's O'Hare airport must be arranged and paid for by the individual. You are welcome to arrive on Wednesday.

Submit Travel Form


The abstracts should be only one or two paragraphs outlining the theme of your presentation and should reflect the objective and spirit of the meeting (see above). Abstracts will be circulated about one week before the meeting. The meeting organizer will start requesting them a month before the meeting.

Submit Abstract

For more than 30 years, the Forbeck Foundation has proven to be an excellent steward of donor funds and has remained focused on executing its mission. Interested in sponsoring this Forum? Contact us today for more information!