Stephen J. Chanock, MD, National Cancer Institute
Adam Shlien, PhD, The Hospital for Sick Children
Jinghui Zhang, PhD, St. Jude Children's Research Hospital
Asilomar Conference Grounds
800 Asilomar Avenue
Pacific Grove, CA 93950
The signatures of mutation in cancer genomes are markers of past mutagen exposure or intrinsic DNA repair defects. Recent studies in childhood cancer have shown that mutational signatures can uncover a tumor’s origin - including whether it arose due to inherited mutation – and point to therapeutic vulnerabilities. In this meeting, we will discuss the enormous potential utility for mutational signatures in childhood cancer, in predicting future outcomes and eligibility to clinical trials, mechanisms for therapy-induced drug resistance, as well as performing “reverse genetics” – understanding the tumor’s past evolutionary trajectory and possible etiology. Knowing that childhood cancers are unique, this meeting’s participants will propose mutational signatures approaches that have been adapted for these patients specifically. This will include focusing on thresholds for detecting underlying mutational signatures, such as mismatch repair and homologous recombination, as well as signatures involving structural rearrangements, which are frequent drivers of childhood cancer malignancy.
Travel forms are due 30 days prior to the start of the meeting to allow enough time to plan transportation.
The Monterey Regional Airport (MRY) is the preferred airport as it is only 20 minutes from the meeting location.
San Francisco International Airport (SFO) is 2 hours from the meeting location without traffic. The Foundation can only accommodate 1 pick up per day at San Francisco. If you absolutely must fly into San Francisco (ie: International Flights) the Foundation will have the following pick up times:
Abstracts are due 30 days prior to the start of the meeting to allow enough time to prepare the meeting book.
Abstracts should be only one or two paragraphs outlining the theme of your presentation and should reflect the objective and spirit of the meeting (see above). Abstracts will be circulated about one week before the meeting. The meeting organizer will start requesting them a month before the meeting.Submit Abstract
|Ludmil Alexandrov, PhD||University of California San Diego|
|Sam Behjati||Wellcome Sanger Institute|
|Paul Brennan, PhD||IARC|
|Stephen Chanock, MD||National Cancer Institute|
|Susan Cohn, MD||University of Chicago|
|Li Ding, PhD||Washington University|
|Sharon Diskin, PhD||Children's Hospital of Philadelphia, Perelman School of Medicine|
|William Foulkes, MD||McGill University|
|Gady Getz, PhD||Broad Institute|
|Erin Guest, MD||Children's Mercy Kansas City|
|Natalie Jäger, PhD||Hopp Children's Cancer Center Heidelberg - KiTZ|
|Katherine Janeway, MD||Dana-Farber Cancer Institute|
|Maria T. Landi, PhD||National Cancer Institute, NIH|
|Nuria Lopez-Bigas, PhD||IRB Barcelona|
|Elli Papaemmanuil, PhD||Memorial Sloan Kettering Cancer Center|
|Stefan Pfister, MD||DKFZ, Hopp Children's Cancer Center Heidelberg|
|Adam Shlien, PhD||The Hospital for Sick Children|
|Uri Tabori, MD||The Hospital for Sick Children|
|Zhaoming Wang, PhD||St. Jude Children's Research Hospital|
|Jinghui Zhang, PhD||St. Jude Children's Research Hospital|
|Andrew Hong, MD||Emory University and Children's Healthcare of Atlanta|
|Emre Kocakavuk, MD||University Hospital Essen & The Jackson Laboratory for Genomic Medicine|
|John Prensner, MD, PhD||Broad Institute/Dana-Farber Cancer Institute|
For more than 35 years, the Forbeck Foundation has proven to be an excellent steward of donor funds and has remained focused on executing its mission. Interested in sponsoring this Forum? Contact us today for more information!