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Mutational Signatures in Pediatric Cancer

January 26–29, 2023

Original Dates: January 28–31, 2021

Chaired By

 Stephen J. Chanock, MD, National Cancer Institute
 Adam Shlien, PhD, The Hospital for Sick Children
 Jinghui Zhang, PhD, St. Jude Children's Research Hospital

Important Dates

 12/27/2022 -  Travel Form Due
 12/27/2022 -  Abstracts Due

Venue Information

Asilomar Conference Grounds
800 Asilomar Avenue
Pacific Grove, CA 93950

About the Forbeck Foundation

 Forbeck Forum Information
 Travel Information
 General Program
 Frequently Asked Questions
 How to donate to WGFRF

Program Description

The signatures of mutation in cancer genomes are markers of past mutagen exposure or intrinsic DNA repair defects. Recent studies in childhood cancer have shown that mutational signatures can uncover a tumor’s origin - including whether it arose due to inherited mutation – and point to therapeutic vulnerabilities. In this meeting, we will discuss the enormous potential utility for mutational signatures in childhood cancer, in predicting future outcomes and eligibility to clinical trials, mechanisms for therapy-induced drug resistance, as well as performing “reverse genetics” – understanding the tumor’s past evolutionary trajectory and possible etiology. Knowing that childhood cancers are unique, this meeting’s participants will propose mutational signatures approaches that have been adapted for these patients specifically. This will include focusing on thresholds for detecting underlying mutational signatures, such as mismatch repair and homologous recombination, as well as signatures involving structural rearrangements, which are frequent drivers of childhood cancer malignancy.

Travel Information

Travel forms are due 30 days prior to the start of the meeting to allow enough time to plan transportation.

The Monterey Regional Airport (MRY) is the preferred airport as it is only 20 minutes from the meeting location.

  • Arrivals - Thursday at 1 PM, 3 PM and 5 PM
  • Departures - Sunday at 10 AM, 12 PM and 2 PM

San Francisco International Airport (SFO) is 2 hours from the meeting location without traffic. The Foundation can only accommodate 1 pick up per day at San Francisco. If you absolutely must fly into San Francisco (ie: International Flights) the Foundation will have the following pick up times:

  • Arrivals - Thursday at 3 PM
  • Departures - Sunday at 10 AM

Submit Travel Form


Abstracts are due 30 days prior to the start of the meeting to allow enough time to prepare the meeting book.

Abstracts should be only one or two paragraphs outlining the theme of your presentation and should reflect the objective and spirit of the meeting (see above). Abstracts will be circulated about one week before the meeting. The meeting organizer will start requesting them a month before the meeting.

Submit Abstract

Forum Participants

Participant Institution
Ludmil Alexandrov, PhD University of California San Diego
Sam Behjati Wellcome Sanger Institute
Paul Brennan, PhD IARC
Stephen Chanock, MD National Cancer Institute
Susan Cohn, MD University of Chicago
Li Ding, PhD Washington University
Sharon Diskin, PhD Children's Hospital of Philadelphia, Perelman School of Medicine
William Foulkes, MD McGill University
Gady Getz, PhD Broad Institute
Erin Guest, MD Children's Mercy Kansas City
Natalie Jäger, PhD Hopp Children's Cancer Center Heidelberg - KiTZ
Katherine Janeway, MD Dana-Farber Cancer Institute
Maria T. Landi, PhD National Cancer Institute, NIH
Nuria Lopez-Bigas, PhD IRB Barcelona
Elli Papaemmanuil, PhD Memorial Sloan Kettering Cancer Center
Stefan Pfister, MD DKFZ, Hopp Children's Cancer Center Heidelberg
Adam Shlien, PhD The Hospital for Sick Children
Uri Tabori, MD The Hospital for Sick Children
Zhaoming Wang, PhD St. Jude Children's Research Hospital
Jinghui Zhang, PhD St. Jude Children's Research Hospital

Forum Scholars

Scholar Institution
Andrew Hong, MD Emory University and Children's Healthcare of Atlanta
Emre Kocakavuk, MD University Hospital Essen & The Jackson Laboratory for Genomic Medicine
John Prensner, MD, PhD Broad Institute/Dana-Farber Cancer Institute

For more than 35 years, the Forbeck Foundation has proven to be an excellent steward of donor funds and has remained focused on executing its mission. Interested in sponsoring this Forum? Contact us today for more information!