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The Genesis and Function of Extrachromosomal Oncogene Amplifications in Cancer

March 24–27, 2022

Original Dates: March 18–21, 2021

Chaired By

 Peter C. Scacheri, PhD, Case Western Reserve University
 Chia-Lin Wei, PhD, The Jackson Laboratory

Important Dates

 02/24/2022 -  Travel Form Due
 02/24/2022 -  Abstracts Due

Travel Agent Information

 Meeting #: Refer to your packet.
 Hours: 8:00am – 8:00 pm EST M-F
 Domestic: 669-210-8002
 International : 623-516-6140

Venue Information

Hilton Denver Inverness
200 Inverness Drive West
Englewood, CO 80112

About the Forbeck Foundation

 Forbeck Forum Information
 Travel Information
 General Program
 Frequently Asked Questions
 How to donate to WGFRF

Program Description

The purpose of this meeting is to explore the formation and function of extrachromosomal DNA (ecDNA) amplifications in cancer. In recent years, driven largely by advances in genomics and DNA sequencing technologies, we have learned that extrachromosomal DNA is far more prevalent in tumors than previously appreciated. ecDNA is present in 20-40% of all human cancers and is particularly common in aggressive cancers notoriously difficult to treat, such as brain cancer. Moreover, our inability to effectively treat cancer is due to an innate ability of ecDNA cancers to evolve in response to environmental stressors. We have further come to learn that circular ecDNAs incorporate active gene enhancer elements that provide a selective growth advantage beyond that of the oncogene alone. This highlights an additional layer of regulatory complexity in canonical cancer driver events that will need to be considered to maximize targeted cancer therapies for patients. This Forbeck Forum seeks to unite investigators focused on ecDNA biology with experts in cancer genetics studying structural variation, epigenomics, and gene regulation. There are several key basic and translational questions that remain unresolved. What genetic processes drive ecDNA formation? What are the “rules” governing regulation of oncogenes on ecDNA? How does ecDNA impact cellular function? Can we use this knowledge to drug previously undruggable targets? We expect the open sharing of new ideas will facilitate collaborations designed to advance our fundamental understanding of how human cancers form and evolve, and how to potentially exploit this new understanding for precision oncology.

ecDNA is a red-hot topic. Industry has expressed a keen interest targeting cancers caused by ecDNA amplifications. The field is poised to make major advances that have translational implications for many cancer patients.

Travel Information

Travel forms are due 30 days prior to the start of the meeting to allow enough time to plan transportation.

Denver International Airport (DIA) is approximately 1 hour from the meeting location.

  • Arrivals - Thursday at 1 PM, 3 PM and 5 PM
  • Departures - Sunday at 10 AM and 12 PM

Submit Travel Form


Abstracts are due 30 days prior to the start of the meeting to allow enough time to prepare the meeting book.

Abstracts should be only one or two paragraphs outlining the theme of your presentation and should reflect the objective and spirit of the meeting (see above). Abstracts will be circulated about one week before the meeting. The meeting organizer will start requesting them a month before the meeting.

Submit Abstract

Forum Participants

Participant Institution
Vineet Bafna, PhD University of California San Diego
Anindya Dutta, MD, PhD University of Alabama at Birmingham
Andrew Fire, PhD Stanford University
Janos Hasko, PhD Aarhus University
Anton Henssen, MD Charité - University Medicine Berlin
Marcin Imielinski, MD, PhD Weill Cornell Medical College
Yonglun Luo, PhD Aarhaus University
Paul Mischel, MD Ludwig Institute for Cancer Research
Birgitte Regenberg, PhD University of Copenhagen
Peter Scacheri, PhD Case Western Reserve University
Clelia Tiziana Storlazzi, PhD University of Bari, Italy
Roel Verhaak, PhD The Jackson Laboratory of Genomic Medicine
Chailin Wei, PhD The Jackson Laboratory of Genomic Medicine
Benjamin Werner, PhD Barts Cancer Institute
Jonathan Whetstine, PhD Fox Chase Cancer Center

Forum Scholars

Scholar Institution
Ofer Shoshani, PhD Ludwig Institute for Cancer Research, UCSD
Massa Shoura, PhD Stanford University School of Medicine
Sihan Wu, PhD Children's Research Institute, UT Southwestern

For more than 35 years, the Forbeck Foundation has proven to be an excellent steward of donor funds and has remained focused on executing its mission. Interested in sponsoring this Forum? Contact us today for more information!