Mechanisms of Cancer Genome Rearrangements

Forum Chairs

Peter
Ly
,
PhD
UT Southwestern Medical Center
Titia
De Lange
,
PhD
Rockefeller University
Isidro
Cortes Ciriano
,
PhD
EMBL-EBI

Forum Description

Mechanisms of Cancer Genome Rearrangements will focus on elucidating the sources and origins of structural genomic alterations arising throughout cancer genome evolution. Specifically, this meeting will serve as the first Forbeck Forum focused on bringing together a diverse group of researchers – ranging from computational cancer genomics to basic experimental biology – in an effort to understand the causes and consequences of complex rearrangements in human cancer genomes.

Rearrangements in the linear chromosome sequence order can directly drive cancer development, as exemplified by a single translocation between chromosomes 9 and 22 (the “Philadelphia chromosome”) in leukemia patients. While simple translocations have long been detectable by cytogenetic approaches, more recent cancer genome sequencing efforts have uncovered a spectrum of novel chromosomal rearrangement patterns across diverse adult and pediatric tumor types, including those with poor prognosis and limited treatment options. Such rearrangements – including chromothripsis and chromoplexy – are often caused by punctuated bursts of genomic instability, which can then promote cancer progression by triggering the loss of tumor suppressor genes, the generation of canonical driver gene fusions, the production of extrachromosomal DNA elements, and/or the development of resistance to chemotherapy. However, we currently have understanding about their mechanisms, functional consequences, and genetic and/or environmental factors that predispose individuals to cancer genome rearrangements. This lack of knowledge has limited our ability to interpret the complex patterns of alterations that are frequently observed in cancer patient genomes. A detailed understanding of these processes will be critical for identifying targetable genetic vulnerabilities associated with genome rearrangements, as well as their use as a potential clinical biomarker. Therefore, a Forum dedicated to bringing together researchers spanning currently disconnected fields (cancer genomics, DNA damage and repair, DNA replication, cell cycle regulation, and clinical oncology) is timely and holds great potential to address the biological basis and clinical implications of complex genomic rearrangements.

This meeting will be organized around four focused sessions addressing the mechanistic basis of complex genomic rearrangements in cancer. Key topics for discussion will include: i) the interpretation of structural variants in cancer patient genomes from DNA sequencing and computational methods; ii) how cells develop, respond to, and repair a spectrum of DNA lesions; iii) how defects throughout the cell cycle can trigger catastrophic consequences at the chromosomal level, and iv) hypotheses underpinning the punctuated evolution of cancer genomes. Junior, mid-career, and established investigators will have the opportunity to present their research in a rigorous yet collegial think-tank environment, which will be interleaved with discussions with a strong focus on biological mechanisms of genomic instability. As organizers, we will encourage the open discussion of unpublished work, concepts, and ideas to promote engagement and the establishment of new collaborations. We believe that the format of the Forbeck Forums is uniquely suited for a focused meeting on this topic, which has not been previously held. Given that diverse expertise and approaches are required to understand cancer genome aberrations, such a Forum holds great potential for unlocking creative thinking and promoting collaborative work. We anticipate that this Forum will foster new, multi-disciplinary interactions across participants who do not typically attend similar meetings, and therefore, we expect that the meeting will translate into synergistic interactions during the Forum and beyond.

Forum Summary

Venue & Travel Information

Inn at Aspen

38750 Highway 82
Aspen, CO 81611

800-525-6200

Travel Forms

Travel forms are due 30 days prior to the start of the meeting to allow enough time to plan transportation.

To help reduce transportation costs, the Foundation tries to group travelers on shuttle vans rather than providing transportation for single travelers.

The Aspen Airport (ASE) is the preferred airport as it is only 10 minutes from the meeting location.
We cannot provide shuttle transportation to or from Denver.

  • Arrivals - Around 1 PM, 3 PM and 5 PM
  • Departures - Around 10 AM and 12 PM
TRAVEL FORMS DUE:
July 18, 2024
submit travel form

Travel Policy

Please familiarize yourself with our policies and procedures for travel. We truly appreciate you taking the time to participate in this meeting. As you make your plans, please remember that we are a nonprofit organization dependent on donations and volunteers. We do NOT pay for upgrades, change fees, incurred costs resulting from a flight change, transportation to or from your local (home side) airport, meals or other incidentals.

  • Travel Confirmation will be sent out within 1 week of the meeting. This will include a hotel confirmation number, if there is one, and airport transfer details. We have to wait until we receive almost everyone’s travel to book airport transfer. Due to frequent airline changes, we wait until the week of the meeting to send this out.
  • Airport transfer is provided by Foundation staff, volunteers or arranged shuttle at specific times. If you opt to utilize Foundation airport transportation on your travel form, please be patient in receiving this information. We will send it to the week of the meeting.
  • Speaker agenda is not sent out prior to the meeting. It will be provided upon arrival in the meeting packet. We do not tell people when they are speaking because we expect everyone to attend all sessions. Sessions are all day Friday and Saturday.
  • REMINDER: We do not reimburse for home side airport transfer or incidentals while traveling. We will not honor miscellaneous receipts sent for these expenses.
  • Spouses are welcome to come with you at their own cost but are not allowed to attend the meeting. Please no children.

What the Foundation Pays

Accommodations and meals are provided by the foundation during the meeting. Airfare will be covered only if booked through our travel agent. The Foundation will also cover airport transportation on the meeting side at the designated shuttle times. You can select not to utilize Foundation arranged transportation at your own expense when completing the travel form. Once your travel form is received your accommodations and airport transfer will be confirmed. Please let us know of any food allergies or other information we should be aware of on the travel forms.

  • If you would like your airfare covered by the Foundation, you must book with our travel agent. Note we do not cover upgrades, changes, late bookings, etc.
  • Flights must be booked at least 30 days prior to the meeting to confirm your accommodations and airport transfer.
  • As a nonprofit we utilize volunteers and other methods to maximize our efforts (or our donor support) when making accommodations and arranging ground transportation. Ground transportation will be provided upon your arrival either by a foundation volunteer or arranged shuttle. You will be provided airport transportation information the week of the meeting. We do not reimburse for home side airport transfer or incidentals while traveling.

Abstracts

Abstracts are due 30 days prior to the start of the meeting to allow enough time to prepare the meeting book.

The abstracts should be only one or two paragraphs outlining the theme of your presentation and should reflect the objective and spirit of the meeting (see above). Abstracts will be circulated about one week before the meeting. The meeting organizer will start requesting them a month before the meeting.

abstracts DUE:
July 18, 2024
submit abstract

Meeting Structure

The meeting structure has been developed over years of experience.

  • Participants have approximately 45 minutes, depending on the number of participants, for their presentation and discussion. The presentation is meant as a conversation start and should last about twenty minutes briefly covering background information and areas that are new or need further input. This should be structured in such a way as to lead to a lively discussion. Participants are encouraged to interrupt to ask questions or start discussions.
  • A MAXIMUM of 5 slide equivalents per presentation is allowed (Power point slides should not contain more than one graph or gel per slide and no more than 5 bullet points to stress the points being made by the presenter.) We appreciate cooperation with the spirit of this guideline. Handouts are welcome but should be distributed before sessions.
  • Everyone is expected to actively participate in every session and discussions.
  • The time spent at the meeting is relatively short, so please be familiar with papers received prior to the meeting.
  • It is very important that you commit to all sessions of the 2 days of meetings.

Forbeck Scholars Participation

Scholars are selected for each Forbeck Forum. These are outstanding junior clinical or post-doctoral fellows selected based on the quality and relevance of science.

  • Scholars present for 30-45 minutes, depending on the number of participants
  • The same presentation rules apply for scholars
  • After the Forum you are selected to attend, you will attend three years of Scholar Retreats held in Lake Geneva, WI. If you attend a Fall Forum, you will attend the Spring Retreat. If you attend a Spring Forum you will attend a Fall Retreat.
  • Scholars are selected by the Foundation Scientific Advisory Board and peer reviewers selected from past Forbeck Scholars.

General Program

The outline below illustrates a typical program schedule. You will receive a complete schedule, including speaking times, the Thursday the meeting starts.

Arrival Day
1:00 PM Arrivals
6:00 PM Cocktails (opt'l)
7:00 PM Dinner
Meeting Day 1
7:00 AM Breakfast
8:00 AM Scientific Sessions
12:00 PM Lunch
1:30 PM Scientific Sessions
6:00 PM Cocktails & Dinner
Meeting Day 2
7:00 AM Breakfast
8:00 AM Scientific Sessions
12:00 PM Lunch
1:30 PM Scientific Sessions
6:00 PM Cocktails & Dinner
Departure Day
7:00 AM Breakfast
8:00 AM Departures

Frequently Asked Questions

Below are some of our most Frequently Asked Questions. If you have something new to ask, please feel free to contact us.

  • Travel Confirmation will be sent out within 1 week of the meeting. This will include a hotel confirmation number, if there is one, and airport transfer details. We have to wait until we receive almost everyone’s travel to book airport transfer. Due to frequent airline changes, we wait until the week of the meeting to send this out.
  • Airport transfer is provided by Foundation staff, volunteers or arranged shuttle at specific times. If you opt to utilize Foundation airport transportation on your travel form, please be patient in receiving this information. We will send it to the week of the meeting.
  • Speaker agenda is not sent out prior to the meeting. It will be provided upon arrival in the meeting packet. We do not tell people when they are speaking because we expect everyone to attend all sessions. Sessions are all day Friday and Saturday.
  • Frequently airport transfer is provided by volunteers. Please be patient on receiving this information. Airport transfer will be sent out prior to arrival.
  • REMINDER: We do not reimburse for home side airport transfer or incidentals while traveling. We will not honor miscellaneous receipts sent for these expenses.

Forum Participants

Floris
Barthel
,
MD
Translational Genomics Research Institute
Peter
Campbell
,
PhD
Wellcome Sanger Institute
Claudia
Carvalho
,
PhD
Pacific Northwest Research Institute
Isidro
Cortes Ciriano
,
PhD
EMBL-EBI
Titia
De Lange
,
PhD
Rockefeller University
Emily
Hatch
,
PhD
Fred Hutchinson Cancer Center
Marcin
Imielinski
,
MD, PhD
Weill Cornell Medicine
Maria
Jasin
,
PhD
Memorial Sloan Kettering Cancer Center
Geert
Kops
,
PhD
Hubrecht Institute
Elena
Kuzmin
,
PhD
McGill University
Peter
Ly
,
PhD
UT Southwestern Medical Center
Paul
Mischel
,
MD
Stanford University Medical Center
Andre
Nussenzweig
,
PhD
National Cancer Institute
Nischalan
Pillay
,
MD, PhD
University College London
Jason
Sheltzer
,
PhD
Yale School of Medicine
Jeremy
Stark
,
PhD
City of Hope
Beth
Sullivan
,
PhD
Duke University
Alejandro
Sweet-Cordero
,
MD
University of California, San Francisco
Alison
Taylor
,
PhD
Columbia University Medical Center
Thomas
Watkins
,
PhD
University College London and the Francis Crick Institute
Cheng-Zhong
Zhang
,
PhD
Dana-Farber Cancer Institute

Forum Scholars

No Scholars attended this meeting