Ribosome Biogenesis and Translation of Cancer
Forum Chairs
Forum Description
This Forum will focus on ribosome biogenesis and translation in cancer, emphasizing their emerging roles as drivers of cancer-specific gene regulation and therapeutic vulnerabilities. Ribosome biogenesis goes beyond making ribosomes. Recent research reveals its expanded role in organizing nuclear and genome architecture, acting as a structural hub that shapes gene expression programs in cancer. These findings redefine the nucleolus and ribosome assembly as active drivers of oncogenic regulation, challenging the dogma of their historical housekeeping functions. Transcription–translation uncoupling points to extensive post-transcriptional control. Across cancers, there is a growing appreciation for the disconnect between mRNA abundance and protein output, highlighting how translation is reprogrammed through specialized ribosomes, RNA modifications (e.g., rRNA, tRNA, mRNA), RNA structure, and regulatory complexes. Targeting mRNA translation in cancer. Cancer cells often exhibit increased reliance on ribosome biogenesis and altered translation machinery. Targeting these processes—such as with RNA-modifying enzyme inhibitors, translation initiation inhibitors, or selective ribosome disruptors—offers a novel and largely untapped therapeutic opportunity. Moreover, it is becoming clear that these types of inhibitors exhibit anti-tumor activity through mRNA-specific mechanisms, pointing to their specificity.
RELEVANCY
Advances in single-cell multi-omics, cryo-EM, nascent proteomics, and spatial transcriptomics have made it possible to dissect ribosome dynamics and translation control in unprecedented detail. It is an exciting opportunity for this meeting to bring together cancer biologists, RNA and ribosome experts, structural biologists, and clinical/translational researchers to integrate these discoveries and set the agenda for the next phase of the field. By fostering interdisciplinary dialogue, this meeting will help accelerate therapeutic innovation rooted in fundamental mechanisms of post-transcriptional gene expression.
GOALS
This meeting aims to catalyze a transformative dialogue among basic, translational, and clinical researchers working at the intersection of RNA biology, ribosome structure, and cancer therapeutics. By bringing together experts in ribosome biogenesis, RNA modification, cryo-EM, nascent proteomics, and translational control, we seek to define the key molecular principles linking translation regulation to tumor biology. The conference will highlight emerging technologies, identify actionable vulnerabilities in ribosome and translation machinery, and foster collaborations to translate mechanistic insights into new treatment strategies. Ultimately, the goal is to build a cohesive community that accelerates the development of ribosome- and translation-targeted therapies for cancer patients.
Important program Note
SPONSOR THIS FORUM
Sponsoring a Forbeck Forum is a powerful way to directly support groundbreaking cancer research by fostering collaboration among top scientists in the field. These intimate, focused meetings bring together leading researchers to share ideas, challenge assumptions, and spark innovative approaches that can accelerate progress toward cures. Your sponsorship helps cover the cost of hosting these unique gatherings, ensuring that vital conversations and partnerships continue to thrive. It's an investment in science, in collaboration, and ultimately, in better outcomes for patients.
Forum Summary
Venue & Travel Information
CONFIRM YOUR ATTENDANCE
The Forbeck Forum is an exclusive, invite-only venue designed for open discussion, knowledge sharing, and collaboration. Limited to just 15-20 participants, this intimate gathering brings together the world’s leading oncology experts to exchange insights and drive innovation in the field.
If you’ve received this invitation, you’ve been recognized as one of the foremost leaders in oncology. Please confirm your attendance by clicking the button below and completing the confirmation form.
We look forward to your participation in this impactful and inspiring event!
Travel Forms
Please familiarize yourself with our travel policy below before booking your travel. If you have any questions about our policy, please do not hesitate to contact us for clarification.
Travel forms are due 30 days prior to the start of the forum to allow enough time to plan transportation.
To help reduce transportation costs, the Foundation tries to group travelers on shuttle vans rather than providing transportation for single travelers.
The Eagle County Regional Airport (EGE) is the preferred airport as it is only 30 minutes from the venue.
We cannot provide shuttle transportation to or from Denver.
- Arrival day of the forum at approximately 1:00 PM, 3:00 PM and 5:00 PM
- Departures from the venue at approximately 8:00 AM, 10:00 AM and 12:00 PM
IMPORTANT INFORMATION ABOUT GROUND TRANSPORTATION
To maximize funding for our Forums, the Foundation does not reimburse ground transportation costs outside the designated shuttle pick-up times. If you arrive after the final shuttle, or do not wish to wait for or take a scheduled shuttle, you will be responsible for arranging and covering your own transportation to the Forum venue.
Travel Policy & General Information
Travel Policy
Please familiarize yourself with our policies and procedures for travel. We truly appreciate you taking the time to participate in this meeting. As you make your plans please remember that we are a nonprofit organization dependent on donations and volunteers. So please note what we do and do not cover.
What the Foundation Pays For
- ACCOMMODATIONS for the nights of the Forum only. People traveling from overseas or far away may arrive 1 night early to adjust for jet lag or to navigate longer travel times.
- MEALS are provided by the foundation during the forum.
- A TRAVEL ALLOWANCE FOR AIRFARE will be set based on an economy ticket from your home airport. If you have travel before or after that is fine. We do not increase the allowance for other travel plans.
- The Foundation provides SHUTTLES TO/FROM THE AIRPORT to the meeting venue at designated shuttle times.
- You can select not to utilize Foundation arranged transportation at your own expense when completing the travel form.
What the Foundation does not cover
- We do not cover upgrades of any kind.
- Travel Allowance will not be increased due to late booking or changes.
- We do not cover incidental costs during your travel. So please do not send your food receipts.
- We do not cover additional nights at the venue outside of the meeting dates.
- We do not cover transportation outside of the designated shuttle times.
- We do not reimburse for home side airport transfer (to/from your home/office to your airport).
Important Things to Note
- Everyone must fill out the travel form!
- We must have your itinerary and travel receipt to receive reimbursement.
- If we do not have your reimbursement information within 3 months after the Forum, reimbursement will not be issued.
- Flights must be booked at least 30 days prior to the meeting or you may not have accommodations and airport transfer.
- We often use volunteers for airport transfers.
- The travel confirmation will be sent out the WEEK before your Forum.
- The speaking agenda will be sent out the NIGHT before your Forum.
- We expect participants to attend ALL sessions.
Frequently Asked Questions
- Travel Confirmation will be sent out within 1 week of the meeting. This will include a hotel confirmation number, if there is one, airport transfer details. We have to wait until we receive almost everyone’s travel to book airport transfer. Also due to frequent airline changes we wait until the week of the meeting to send this out.
- Speaker agenda is not sent out prior to the meeting. It will be provided upon arrival in the meeting packet. We do not tell people when they are speaking because we expect everyone to attend all sessions. Sessions are all day Friday and Saturday.
- Frequently airport transfer is provided by volunteers. Please be patient on receiving this information. Airport transfer will be sent out prior to arrival.
Abstracts
Abstracts are due 30 days prior to the start of the meeting to allow enough time to prepare the meeting book.
The abstracts should be only one or two paragraphs outlining the theme of your presentation and should reflect the objective and spirit of the meeting (see above). Abstracts will be circulated about one week before the meeting. The meeting organizer will start requesting them a month before the meeting.
Forum Structure
The structure of the forum has been developed over years of experience.
- Participants have approximately 45 minutes, depending on the number of participants, for their presentation and discussion. The presentation is meant as a conversation start and should last about twenty minutes briefly covering background information and areas that are new or need further input. This should be structured in such a way as to lead to a lively discussion. Participants are encouraged to interrupt to ask questions or start discussions.
- Each presentation is limited to 2 slide equivalents. Slides should include no more than one graph or gel per slide and a maximum of 5 bullet points. Avoid animations or motion effects. Slides should support discussion, not serve as a script. Thank you for adhering to the spirit of this format.
- A Whiteboard and markers will be available to supplement your digital slides.
- Everyone is expected to actively participate in every session and discussions.
- The time spent at the forum is relatively short, so please be familiar with papers received prior to arrival.
- It is very important that you commit to all sessions of the 2 days of the forum.
Forbeck Scholars Participation
Scholars are selected for each Forbeck Forum. These are outstanding junior clinical or post-doctoral fellows selected based on the quality and relevance of science.
- Scholars present for 30-45 minutes, depending on the number of participants
- The same presentation rules apply for scholars
- After the Forum you are selected to attend, you will attend three years of Scholar Retreats held in Lake Geneva, WI. If you attend a Fall Forum, you will attend the Spring Retreat. If you attend a Spring Forum you will attend a Fall Retreat.
- Scholars are selected by the Foundation Scientific Advisory Board and peer reviewers selected from past Forbeck Scholars.
Program
The schedule below outlines the official program for this forum. A detailed agenda, including individual speaking times, will be provided on the first day of the event.
Frequently Asked Questions
Below are some of our most Frequently Asked Questions. If you have something new to ask, please feel free to contact us.
- Travel Confirmation will be sent out within 1 week of the forum. This will include a hotel confirmation number, if there is one, and airport transfer details. We have to wait until we receive almost everyone’s travel to book airport transfer. Due to frequent airline changes, we wait until the week of the meeting to send this out.
- Airport transfer is provided by Foundation staff, volunteers or arranged shuttle at specific times. If you opt to utilize Foundation airport transportation on your travel form, please be patient in receiving this information. We will send it the week of the forum.
- Speaker agenda is not sent out prior to the meeting. It will be provided upon arrival in the meeting packet. We do not tell people when they are speaking because we expect everyone to attend all sessions. Sessions are all day.
- Frequently airport transfer is provided by volunteers. Please be patient on receiving this information. Airport transfer will be sent out prior to arrival.
- REMINDER: We do not reimburse for home side airport transfer or incidentals while traveling. We will not honor miscellaneous receipts sent for these expenses.
Forum Participants
Forum Scholars
Photos
PODCAST
