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Tumor Microenvironment

November 1–4, 2018

Chaired By

 Lisa M. Coussens, PhD of Knight Cancer Institute
 Rakesh K. Jain, PhD of Massachusetts General Hospital

Meeting Description

All cancers contain diverse populations of cells, including those harboring genetic mutations, aka "tumor" or "cancer" cells, as well as other "normal" cell types activated and/or recruited to local tumor microenvironments. Both preclinical and clinical data indicate that components of the tumor microenvironment (e.g., blood and lymphatic vessels, fibroblasts and other mesenchymal support cells, innate and adaptive immune cells, as well as extracellular matrix, hypoxia, and low pH), while regulating hallmark features of cancer development, can also thwart efficacy of cytotoxic, targeted and new-age immune therapies. This Forbeck Foundation meeting will bring together existing and emerging thought leaders spanning the breadth of tumor microenvironment, immune-oncology and computational biology disciplines to discuss novel approaches to identify critical mechanisms regulating crosstalk between neoplastic and "host" cells, with an emphasis on those that subvert anti-tumor immunity. We will also discuss therapeutic approaches to target aspects/components of the tumor microenvironment that effectively liberate anti-cancer immunity for durable tumor control, how these strategies are being deployed in patients, and initial clinical findings.

The 2018 Forum on Tumor Microenvironment will be chaired by Dr. Rakesh K. Jain of Massachusetts General Hospital and Harvard Medical School, and Dr. Lisa M Coussens from the Knight Cancer Institute at Oregon Health & Science University. The goal will be not only to discuss the current state of the tumor microenvironment field, but also discuss approaches towards applying that knowledge to the development of effective and broadly applicable anti- cancer therapies for long-term management of disease.

Meeting Summary
Forum summary not available at this time.
Forum Participants

Peter Carmeliet, MD, PhD
Center for Cancer Biology, VIB-KU Leuven Belgium

Lisa Coussens, PhD
Oregon Health & Science University

David G. DeNardo, PhD
Washington University School of Medicine

Stephanie K. Dougan, PhD
Dana-Farber Cancer Institute

Mikala Egeblad
Cold Spring Harbor Laboratory

Ronald N. Germain, MD, PhD
NIAID, National Institute of Health

Richard O. Hynes, PhD
Koch Institute for Integrative Cancer Research at MIT

Rakesh Jain, PhD
Massachusetts General Hospital

Elaine R. Mardis, PhD
Nationwide Children's Hospital

Daniela Quail, PhD
McGill University

Melodie Swartz, PhD
University of Chicago

David Tuveson, MD, PhD
Cold Spring Harbor Laboratory

Matthew Vander Heiden, MD, PhD
Koch Institute at MIT

Jennifer Wargo, MD
MD Anderson Cancer Center

Irv Weissman, MD
Stanford University