3D Chromosomal Architecture and Nuclear Topology

May 2nd - 5th, 2019



Chaired By

 Ari Melnick, MD - Cornell Medical College
 Jane Skok, Ph.D. - New York University Medical School


Important Dates

 03/02/2019 - Travel Forms - Travel Form )
 04/02/2019 - Abstracts


Venue Information

Estancia La Jolla Hotel and Spa
9700 North Torrey Pines Road
La Jolla, CA 92037
855.318.7602

www.meritagecollection.com


Travel Agent Information

 Meeting #: Refer to your packet.
 Hours: 8:00am – 8:00 pm EST M-F
 Domestic: 669-210-8002
 International : 623-516-6140


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Program Description

The precise and detailed 3D organization of chromosomal and chromatin looping is just now being understood to play a fundamental role in regulation of gene expression, DNA repair, DNA replication and cell cycle. Disruption of nuclear topology is a emerging as a potential new hallmark of cancer. For example somatic mutation of the loop and boundary protein CTCF are prevalent in many types of cancer, as are mutations of the various proteins that make up or regulate the cohesin complex that plays a central role in architectural effects. In addition there is rapidly increasing body of evidence that somatic mutation of looping elements can drive development of cancerby either disrupting the location of large gene enhancer clusters, boundary elements, lncRNAs that strengthen looping, and binding affinity of regulatory DNA elements for proteins that drive specific 3D architectural features.

Moreover it seems like master regulatory transcription factors may mark sites for preferential redistribution of 3D anchor points of various kinds. There are many new and fascinating observations coming out, novel mouse models, patient based observations. There is tremendous excitement currently about this new frontier in biology and its relation to cancer. I have chaired special lecture sessions on this for example at the AACR annual meeting and other venues. A conference on this new and very hot topic would be very impactful in disseminating ideas and creating new avenues of attack for understanding how nuclear topology drives normal and malignant biology, and perhaps generating some ideas on how the study of this novel field could lead to biomarkers and therapies for cancer patients.


Participant Information

Participant Institution
Eftychia Apostolou, PhD Weill Cornell Medicine
Gerd A. Blobel, MD, PhD University of Pennsylvania Pearlman School of Medicine
Wouter De Laat, PhD Hubrecht Institute
Peter Fraser, PhD Florida State University
Susana Hadjur, University College London
Ross Levine, MD Memorial Sloan Kettering Cancer Center
Mathieu Lupien, PhD University of Toronto
Ari Melnick, MD Cornell University
Leonid Mirny, PhD, M.Sc Massachusetts Institute of Technology
Kim Nasmyth, PhD Trinity College of Oxford University
Clodagh O'Shea, PhD Salk Institute for Biological Studies
Tomi Pastan, MD, PhD University of Missouri-Kansas City
Jan-Michael Peters, Research Institute of Molecular Pathology
Jennifer E. Phillips-Cremins, PhD University of Pennsylvania
Ana Pombo, Max Delbruch Center for Molecular Medicine
Bing Ren, PhD Ludwig Cancer Research
Benjamin Rowland, Netherlands Cancer Institute
Peter Scacheri, PhD Case Western Reserve University
Jane Skok, PhD NYU Langone Health
Francois Spitz, Pasteur Institute

Airport Information

San Diego International Airport (SAN) is approximately 30 minutes from the meeting location.

  • Arrivals - Thursday at 3 PM, 5 PM and 7 PM
  • Departures -

International participants are welcome to arrive on Wednesday to minimize chances for missed or delayed connections.


Abstracts

The abstracts should be only one or two paragraphs outlining the theme of your presentation and should reflect the objective and spirit of the meeting (see above). Abstracts will be circulated about one week before the meeting. The meeting organizer will start requesting them a month before the meeting.