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Cancer and Genomic Dark Matter

May 12–15, 2022



Chaired By

 Kathleen H. Burns, MD, PhD of Harvard
 Ting Wang, PhD of Washington University


Important Dates

 01/12/2022 -  Travel Form Due
 02/12/2022 -  Abstracts Due


Travel Agent Information

 Meeting #: Refer to your packet.
 Hours: 8:00am – 8:00 pm EST M-F
 Domestic: 669-210-8002
 International : 623-516-6140


Venue Information

Asilomar Conference Grounds
800 Asilomar Avenue
Pacific Grove, CA 93950
831.372.8016

www.visitasilomar.com


About the Forbeck Foundation

 Forbeck Forum Information
 Travel Information
 General Program
 Frequently Asked Questions
 How to donate to WGFRF


Program Description

Transposable elements (TEs) make up 50% of the human genome but are referred to as "genomic dark matter" or "junk DNA" and often ignored in genomic medicine - both because they have been presumed to be unimportant and because their high copy number and variability pose unique technical challenges. Neither impediment now seems steadfast. Interest in the human transposable elements and their role in cancer has never been greater, and methods enabling its study are maturing at a fast pace.

Transposable elements directly contribute to cancer through both genetic and epigenetic mechanisms. De novo transposon insertions are known to disrupt important genes and gene regulatory elements and result in tumorigenesis. Epigenetically reactivated transposable elements can become cryptic promoters and enhancers and lead to abnormal gene activities including up-regulating oncogenes. These recent mounting evidences request a full understanding of the contribution of transposable elements to cancer.

On the other hand, transposable elements are a double-edged sword. Recent discoveries reveal that epigenetically reactivated transposable elements can produce cancer specific products including immunogenic antigens and double stranded RNAs, which result in an innate immune response. These findings together with rapid development of immunotherapies open new avenues for cancer treatment.


Forum Participants

Participant Institution

Forum Scholars

Scholar Institution
Carlos Mendez-Dorantes, PhD Dana-Farber Cancer Institute

Airport Information

The Monterey Regional Airport (MRY) is the preferred airport as it is only 20 minutes from the meeting location.

  • Arrivals - Thursday at 1 PM, 3 PM and 5 PM
  • Departures - Sunday at 10 AM, 12 PM and 2 PM

Mineta San Jose International (SJC) is 1 1/2 hours from the meeting location without traffic. The Foundation can only accommodate 1 pick up per day at San Jose. If you absolutely must fly into San Jose (ie: International Flights) the Foundation will have the following pick up times:

  • Arrivals - Thursday at 4 PM
  • Departures - Sunday at 10 AM

San Francisco International Airport (SFO) is 2 hours from the meeting location without traffic. The Foundation can only accommodate 1 pick up per day at San Francisco. If you absolutely must fly into San Francisco (ie: International Flights) the Foundation will have the following pick up times:

  • Arrivals - Thursday at 3 PM
  • Departures - Sunday at 10 AM

Submit Travel Form

Abstracts

The abstracts should be only one or two paragraphs outlining the theme of your presentation and should reflect the objective and spirit of the meeting (see above). Abstracts will be circulated about one week before the meeting. The meeting organizer will start requesting them a month before the meeting.

Submit Abstract

For more than 30 years, the Forbeck Foundation has proven to be an excellent steward of donor funds and has remained focused on executing its mission. Interested in sponsoring this Forum? Contact us today for more information!